Within the final twenty years, several studies demonstrated the significance of submit-translational modifications (PTM) in cellular development and several ailments like most cancers, but just lately protein lysine methylation has emerged as an one other vital PTM.

Methylation been found on a variety of lysine residues in varied histones: K4 (utilizing the only-letter amino-acid code for lysine), K9, K27, K36 and K79 in histone H3, K20 in histone H4, K59 in the globular area of histone H4 2 and K26 of histone H1B three A number of proteins accountable for the methylation of specific residues have been characterised, and all but certainly one of these contains a SET domain